Growth factor receptor tyrosine kinases (RTKs), such as the fibroblast growth factor receptor (FGFR), play a major role in how cells communicate with their environment. FGFR signaling is crucial for normal development, and its misregulation in humans has been linked to developmental abnormalities and cancer. The precise molecular mechanisms by which FGFRs transduce extracellular signals to effect specific biologic responses is an area of intense research. Genetic analyses in model organisms have played a central role in our evolving understanding of (...) these signal transduction cascades. Genetic studies in the nematode C. elegans have contributed to our knowledge of FGFR signaling by identifying genes involved in FGFR signal transduction and linking their gene products together into signaling modules. This review will describe FGFR-mediated signal transduction in C. elegans and focus on how these studies have contributed to our understanding of how FGFRs orchestrate the assembly of intracellular signaling pathways. BioEssays 23:1120–1130, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Kitāb Shifāʾ al-asqām al-ʿāriḍa fī l-ẓāhir wa-l-bāṭin min al-ajsām li-l shaykh sayyid Aḥmad b. ʿUmar al-Raqqādī al-Kuntī. Edited by Floréal Sanagustin. VECMAS. 3 vols. Lyons: ENS Éditions, 2011. Pp. v + 167 ; v + 147 ; iv + 133.

Food choices are a key determinant of dietary intake, with brain regions, such as the mesolimbic and prefrontal cortex maturing at differential rates into adulthood. More needs to be understood about developmental changes in healthy and unhealthy food perceptions and preference. We investigated how food perceptions and preference vary as a function of age and how food attributes impact age-related changes. One hundred thirty-nine participants completed computerized tasks to rate high-calorie and low-calorie food cues for taste, health, and liking, followed (...) by 100 binary food choices based on each participant’s ratings. Dietary self-control was considered successful when the healthier food was chosen. Self-control success ratio was the proportion of success trials over total number of choices. Beta-weights for health and taste were calculated as each attribute’s influence on food preference. Adiposity measurements included BMI z-score and waist-to-height ratio. High-calorie foods were rated more tasty and less healthy with increasing age. Older participants liked high-calorie foods more, and β-taste was associated with age. Significant age-by-WHtR interactions were observed for health and taste ratings of high-calorie foods, β-taste, and marginally for preference of high-calorie foods. Stratifying by WHtR, we found age-related increases in taste and preference ratings of high-calorie foods in the high WHtR group alone. In contrast, age-related decreases in health ratings of high-calorie foods were significant in the low WHtR group alone. Age and β-taste were significantly associated in the high WHtR group and only marginally significant with low WHtR. Although participants rated low-calorie foods as less tasty and less healthy with increasing age, there was no association between age and preference for low-calorie foods. Participants made faster food choices with increasing age regardless of WHtR, with a significant age-by-WHtR interaction on reaction time. There were no age-related effects in self-control success ratio and β-health. These results suggest that individual differences in age and central adiposity play an important role in preference for high-calorie foods, and a higher importance of food tastiness in food choice may contribute to greater preference for high-calorie foods with increasing age. (shrink)

Der Band verzeichnet erstmals sämtliche Werke und Noten aus Nietzsches persönlicher Bibliothek (BN) bis Anfang Januar 1889. Er listet sowohl die Bestände der Herzogin Anna Amalia Bibliothek als auch die des Goethe- und Schiller-Archivs in Weimar auf. Die kritische Analyse anderer Bestandslisten ermittelte zudem zahlreiche heute nicht mehr vorhandene Titel. Ferner wurden sämtliche Bücherrechnungen und -quittungen von Buchhändlern und Buchbindern ausgewertet, die im Goethe- und Schiller-Archiv aufbewahrt werden. Neben den ca. 2.200 Titeln aus Nietzsches rekonstruierter Bibliothek enthält der Band auch (...) ein Verzeichnis sämtlicher 'Lesespuren' Nietzsches (ca. 20.000), z.B. Anmerkungen, Unterstreichungen und Eselsohren. Ergänzt durch zahlreiche Faksimile-Reproduktionen sowie durch philosophische, historische und bibliographische Einführungen, stellt der Band ein unverzichtbares Arbeitsinstrument jeder zukünftigen Nietzsche-Forschung dar. (shrink)

"The twelve chapters of this volume all began their existence as contributions to workshops held between 2009 and 2011 by a Danish-Swedish research network called The Aristotelian Tradition: The reception of Aristotle's works on logic and metaphysics in the Middle Ages, headquartered in Gothenburg and funded by the Bank of Sweden Tercentenary Foundation. Most of them were written by members of the network, some by invited speakers. While the volume amply illustrates the set of scholarly approaches characteristic of the "Copenhagen (...) School of Medieval Philosophy" (notably a strong philological foundation and an interest in ancient as well as medieval and Greek as well as Latin texts), its thematic diversity reflects the network's breadth of interests. What unites the chapters in this respect is simply a concern with different historical manifestations of Aristotelian thought on logical and metaphysical matters. The volume includes studies of texts by, among others, Apuleius, Boethius, Anonymus Aurelianensis III, Michael of Ephesus, Averroes, Anonymus Cantabrigiensis, Nicholas of Paris, Robert Kilwardby, Anonymus O, Thomas Aquinas, William of Ockham, and Francisco Suárez, relating to themes and passages in Aristotle's Categories, On Interpretation, Prior Analytics 1, Posterior Analytics 1, Sophistical Refutations and Metaphysics A and Z. The last two chapters consist of a new edition, with English translation and commentary, of the first part of a fiercely anti-Aristotelian work, which has been described as the starting-point for Renaissance Platonism and Aristotelianism alike: George Gemistos Plethon's On Aristotle's Departures from Plato."--. (shrink)

The purpose of this article is to show the Roman home theater of Queen Marie Casimire Louise de La Grange d’Arquien as a topic she addressed in her letters. The sources are based on her correspondence with her eldest son; these sources are one-sided, as only the queen’s letters are known, while the letters of Prince James have not survived or have not been found. In 1698, the widowed Marie Casimire left Poland and moved to Rome to spend the Jubilee (...) year there. Eventually, she remained on the Tiber for almost fifteen years. Following in the footsteps of Queen Christina, she wished to be a patron of artists, and since she had already organized theatrical performances at her court in Poland, she decided to patronize musical, theatrical and operatic performances in Rome as well. She was assisted in this endeavor by Prince Alexander, who also resided in Rome. It soon became apparent that her son was not only an active patron, but also had artistic talents and an aptitude to take on the role of director, writer, and even a dancer in ballet scenes. The queen’s granddaughter and namesake, Marie Casimire, was also involved in preparing the performances. At her uncle’s side, she learned the art of preparing performances, but she also took part in ballet scenes. In her letters to her eldest son, James, the queen marveled at the versatile talents of both and assured him that she would spare no expense or effort to provide them with opportunities to entertain, and to bring splendor and widespread acceptance to herself and her theater. In her correspondence, the Queen never touched on the topic of the plays themselves, gave their titles, or wrote anything about the subjects they addressed. From the Queen’s correspondence, one cannot learn much about her home theater, but much about the pride that filled her at the thought of her son’s and granddaughter’s artistic achievements. The letters are a testimony to the queen’s feelings, not a report of the life of her Roman court. (shrink)

In this paper, we introduce the concept of policy malaise, which refers to citizens’ dissatisfaction with the way political institutions and processes handle specific problems such as the refugee issue in Germany. Based on a representative online panel survey with two waves conducted in 2016 and 2017 (N = 836), we explore the occurrence of policy malaise among the German population and its relation to issue-specific media use, trust in news media, and issue fatigue. First, the results indicate that policy (...) malaise toward the refugee issue is widespread in Germany. Second, we found that media use relates differentially to policy malaise: While high exposure to public broadcasting was negatively associated with policy malaise, we found the opposite for private broadcasting. Third, policy malaise is higher for people who experience issue fatigue and lower for people who trust the news media. Finally, trust in media reinforces the negative and positive relations between media use and policy malaise. Implications concerning the associations between policy malaise and political alienation in its broader sense are discussed. (shrink)

Classic publishing of Eastern philosophy, religion, and poetry. This is a facsimile edition of the work originally published in London by John Murray in 1940.

Post-structuralist discourses have usually been associated with forms of critique and deconstruction of social, cultural and philosophical phenomena. However, this article attempts to provide a generative approach to understanding educational leadership through Michel Foucault’s notions of power and subjectification, and Judith Butler’s notions of performativity and discursive agency through re-signification. We argue that leadership is not simply a list of traits, characteristics or behaviours to be implemented. Rather, we argue that leaders are performatively constituted through everyday practices and discourses. The (...) aim is to interrupt prevailing discourses that often re-inscribe certain forms of meaning and understanding in educational leadership. This disruption subsequently provides possibility for putting forward otherwise silenced ideas about what leadership is and how leadership ‘identity’ (subjectivity) is formed, thus expanding the methodological tools scholars can use to talk about leadership. (shrink)

This book explores the nature and implications of positive, creative, and loving mimesis and brings together the interdisciplinary fields of Girardian studies and creativity studies in new and original ways. Scientists, philosophers, psychologists, theologians and ancient thinkers are brought into thought provoking and insightful dialogue with Girardian conceptions of mimetic desire, scapegoating, and hominization.

Emerging trends in the workforce point to the necessity of facilitating work lives that foster constructive and balanced relationships between professional and private spheres in order to retain employees. Drawing on the conservation of resources theory, we propose that motivational climate influence turnover intention through the facilitation of work–home spillover. Specifically, we argue that employees working in a perceived mastery climate are less likely to consider voluntarily leaving their employer because of increased positive—and reduced negative—work–home spillover experiences. We further argue (...) that employees working in a perceived performance climate are more likely to consider voluntarily leaving their employer because of reduced positive—and increased negative—work–home spillover experiences. In a cross-lagged survey of 1074 employees in a Norwegian financial-sector organization, we found that work–home spillover partly mediates the relationship between a perceived mastery climate and turnover intention. Specifically, mastery climates seem to facilitate positive—and reduce negative—spillover between the professional and private spheres, which in turn decreases employees’ turnover intention. We discuss implications for practice and future research. (shrink)

It is proved that equations between arrows assumed for cartesian categories are maximal in the sense that extending them with any new equation in the language of free cartesian categories collapses a cartesian category into a preorder. An analogous result holds for categories with binary products, which may lack a terminal object. The proof is based on a coherence result for cartesian categories, which is related to model-theoretic methods of normalization. This maximality of cartesian categories, which is analogous to Post (...) completeness, shows that the usual equivalence between deductions in conjunctive logic induced by βη normalization in natural deduction is chosen optimally. (shrink)

Die Sophisten waren und sind umstritten. In der Zeit des Perikles, der Hochblüte der griechischen Kultur, als Wanderlehrer in Griechenland tätig, bewirkten sie mit ihrer Lehrtätigkeit, welche die verschiedensten Wissensgebiete umfasste, einen grundlegenden Blickwandel: Ihre Befassung mit Erkenntnistheorie, Rhetorik und Politik lenkte den Blick vom Kosmos zurück auf den Menschen. Indem sie den Menschen in den Mittelpunkt ihres Denkens stellten, ja ihn sogar zum Maß aller Dinge erklärten, wendeten sie sich zugleich gegen die traditionelle Sittlichkeit, die in der Regel religiös (...) begründet war. So waren sie für die einen gefeierte Aufklärer, für die anderen jedoch Zerstörer der Tradition. Diese Ambivalenz in der Einschätzung ihres Wirkens ist bis heute geblieben. Was auch geblieben ist und von Moderne wie Postmoderne aufgenommen wurde, sind wesentliche Ansätze ihres Denkens: z. B. ihr erkenntnistheoretischer Relativismus, ihre Vertragstheorie und ihre Lehre vom Recht des Stärkeren. Weil ihr Denken so aktuell ist, untersucht der vorliegende Band nicht nur die antiken Sophisten, sondern vergleicht sie auch mit ihren modernen und postmodernen Wiedergängern wie bspw. Nietzsche, Butler und Foucault. Mit Beiträgen von Viktoria Bachmann, Thomas Buchheim, Bettina Fröhlich, Benjamin Hahn, Hendrik Hansen, Raul Heimann, Johannes Hoerlin, Vanessa Jansche, Christina Kast, Peter Kainz und Barbara Zehnpfennig. (shrink)

��In four experiments we address the question whether several visual objects can be selected voluntarily (exogenously) and then tracked in a Multiple Object Tracking paradigm and, if so, whether the selection involves a different process. Experiment 1 showed that items can indeed be selected based on their labels. Experiment 2 showed that to select the complement set to a set that is automatically (exogenously) selected — e.g. to select all objects not flashed — observers require additional time and that given (...) 1080 ms they were able to select and track them as well as those selected automatically. Experiment 3 showed that the additional time needed in the previous experiment cannot be attributed solely to time required to disengage attention from the initially automatic selections. Experiment 4 showed that the added time provides a monotonically greater benefit when there are more targets, suggesting a serial process. These results are discussed in relation to the Visual Index (FINST) theory which assumes that visual indexes are captured by a data-driven process. It is suggested that voluntarily allocated attention can be used to facilitate the automatic attention capture by objects of interest. (shrink)

Este artículo analiza en dos escritos en primera persona, de Ángel Cuervo y Tomás Cuenca, la idea de paz en la Guerra por las Soberanías, que enfrentó a las fuerzas oficialistas del gobierno conservador presidido por Mariano Ospina con las de los liberales lideradas por Tomás Cipriano de Mosquera. A partir del análisis de ambos textos vistos en correlación con el contexto y con documentación de época de diversa índole, se estudian algunos avenimientos y de qué modo se incorpora el (...) derecho de gentes y los mecanismos de contención de la guerra que desembocó en la promulgación del artículo 91 de la Constitución de 1863. (shrink)

A common sentiment among anti-sex-robot scholars is the apprehension that sex robots will normalize and perpetuate sexual violence towards humans. In this new chapter within the feminist sex war, the authors of this article tend to agree with anti-sex-robot concerns and seek to further identify potential harms of sex robots. However, instead of characterizing the harm in terms of what the robots represent and symbolize, we are primarily interested in the internal state of the user and the type of relationship (...) that will emerge between human users and sex robots, which we argue is an unprecedented sexual relation. Unlike other comparable sex products and services, sex robots occupy a liminal space between being perceived as both a sexual property and agent, oscillating based on the preferences and convenience of the user. We argue that this oscillation that enables human–sex robot intimacy requires self-deception, which in turn entails individual moral responsibility. Thus, we articulate a novel virtue-based approach of examining human–robot intimacy that focuses on cultivating erotic flourishing. We conclude that people have a moral responsibility to exhibit self-awareness within the dynamics of their intimate relationship with sex robots and the (contradictory) beliefs required to maintain such intimacy. (shrink)

The concept of virtue was of great interest and importance for H. Cohen. In the interpretation of this concept in his latest work “Religion of reason from the sources of Judaism” the most important concepts of this work were brought in the focus: the specificity of definition of what is the religion of reason; understanding of the uniqueness of God; correlation; messianism. For Cohen, a single system of virtues presupposes a single and unique ethics and correlates with the idea of (...) the unity of humanity. The last concept, in his opinion, maturated in the fold of monotheism. Humanity is one, because all people are creations of the unique God. “Religion of reason” treats of the common universal virtues. In the religion of reason, the idea of God and morality are inextricably linked. Cohen rejects metaphysical speculation about the nature of God, about the attributes of God inherent in himself. The religion of the mind speaks of God only in correlation with man. God is a moral ideal and reveals himself to man by giving him moral commandments. Morality connects man and God, and this connection is revealed in detail by Cohen in the theme of virtues. Understanding God as Truth is important for the disclosure of this topic. The corresponding virtue for a person is faithfulness to truth, or truthfulness. In addition to truthfulness in the usual sense, for Cohen, faithfulness to truth requires correct worship of God. The correlation culminates in the idea of messianism, which is interpreted by Cohen as an endless movement of a whole humanity to the social justice. (shrink)

The Phaedo and the Symposium are dialogues in which Plato's conception of philosophy is not dissociated of orphic elements and mythical constructions. I propose that the themes of the pre-existence of the soul and the immortality of the soul in the Phaedo and myths told by Aristophanes and Diotima in the Symposium, examined together, provide rich material for understanding the nature and limits of knowledge and philosophy in Plato. I also suggest, before this interpretation, a reading of the "sudden vision (...) of beauty in itself," in Symposium 210e, which takes into account these limits. Knowledge is, from this reading, a dynamic search, much more than intuition of the forms. (shrink)

Name der Zeitschrift: Das Mittelalter Jahrgang: 22 Heft: 2 Seiten: 259-266.

The Ottoman legal system is built on religious (sharīʿa) and customary (ʿurfī) laws. The customary law consists of the rules that are not in contrast to the sacred law. Collection of regulations (qānūnnāme) were the most effective way for the execution of the customary laws. The qānūnnāme included the sultan’s orders and edicts (farman). Ottomans regulated and evaluated the taxes through measurements of lands specific times of the year. These measurements would be recorded into the taḥrīr books (written survey of (...) immovable prop-erties). And the administrative qānūnnāme were included in these books. In the qānūnnāmes, we can find information about the taxes, and the unlawful executions of the customary actors (ahl al-ʿurf) as well as the tax regulations. The qānūnnāmes on sanjak are composed accord-ing to the economic, social, and geographical characteristics of the administrative district it is written about, and with this, they provide us information on these issues. In this article, three sanjak qānūnnāmes are taken as the central topic and Kamah, Āmid, Pojega are evaluated in terms of the execution of customary law in these districts. These qānūnnāmes include record-ings of various taxing regulations, altered and cancelled executions, amounts of taxes, and punishments. We can compare the three districts in their economic and social characteristics.Summary: The Ottoman legal system consists of sharia and customary law. Ordinary law is based on some regulations which the sultan deems necessary and is composed of laws. The Ordinary law should not contradict sharia. When the Ottomans conquered a place, they generally protected the current laws (such as Uzun Hasan's laws), except for necessary changes or cancellations. When the Ottomans conquered a place, they used to make census to determine taxes. As a result of this census, Sanjak qānūnnāmes were placed in taḥrīr books. It also involves issues such as public and criminal law, customary tax regulations, and amounts of market taxes, which are approved by the emperor. In this article, the Sanjak qānūnnāmes of different regions belonging to the period of Suleiman the Magnificent, whose dates are close to each other, were selected. The Sanjak qānūnnāmes which are studied on are Kemah sanjak of Erzurum province belonging to (937/1530) and Āmid sanjak of Diyarbekir province belonging to (947/1540) and Pojega sanjak of Budin province belonging to (950/1545). The reason for this is to be able to compare the differences or stableness in tax and practices in the mentioned date range. At the same time, attention has been paid to the effectiveness of customary practices and the parts that are linked to sharīʾa. Some of the laws of Uzun Hasan are in force in Kemah and Amid. In these two sanjaks, some of the bâc taxes and some other taxes were removed. It is seen that the complaints made by the public due to the excess of taxes are taken into consideration. For example, in Kemah, the akche of murahhasiyye paid by the villagers for Armenian priests and bishops is one of them. The taxes that are abolished include kulluk and blend tax and taxes from various business lines. The tax, which was collected by the governors of the sanjak and the castle beys under the name of custom, which was imposed by some local administrators, was cancelled by seeing bidat. When three of the sanjaks are taken together, there are cautions that unfair and unlawful tax collections made by local administrators during tax collection have been abolished and these are accepted as bidat. Kemah sanjak qānūnnāme is 13 pages in total. Kemah, which has a geographical position and military transit route, has commercial relations with cities such as Trabzon and Hasankeyf. In Kemah, there are candle mill (şemhane), creamery (bezirhane) and tavern (meyhane). Kemah is one of the places where the climate has an impact on agriculture. Kemah's economy is based on trade, agriculture, small livestock, beekeeping. In Kemah, where caravan trade is important, trade goods are of value due to its location on the transit road. The Kemah qānūnnāme also contains various taʿzīr for unjust killing, wounding, and adultery. In the city, there are some arcs have ownership in common. The fact that there are mills indicates that the rivers in Kemah are utilized. Âmid Sanjak qānūnnāme consists of two pages. The title that attracts our most attention is that there is vitality and economic activity in the market since Âmid is on the Aleppo-Mosul Silk Road. The high number of weaving looms is due to the production of cotton. Amid has dye house and saphane. Indigo and Amid's red dye sold in the market shows the importance of weaving. Pojega sanjak qānūnnāme is composed of seven pages. Among the qānūnnāmes we have mentioned, this is the most legible one. In addition to the old practices, there are some new regulations in this qānūnnāme. The pig tax is only here because of the non-Muslim population. Transit tax fees indicate trading viability. Based on the studies made on these three sanjaks, it can be said that in the qānūnnāme, the rights of the raia (reaya) were tried to be protected by the rescript of the Sultan himself. Therefore, the most remarkable things in the qānūnnāme are not allowed unfair practices of local administrators and without the need to collect taxes from the public. The dates of the qānūnnāme are close to each other and Despite geographical differences, there is no remarkable change in taxation. Although there are non-Muslim populations in all three sanjaks, it is mostly in the Pojega sanjak. The fact that the pig tax is collected only from this sanjak is evidence of this situation. The presence of meyhane in Kemah, Amid and Pojega sanjaks point to the non-Muslim population. It is also used as a place where the villagers sell their grape juice. The mill tax on Kemah and Pojega show that rivers are used in common. (shrink)

Автором рассматриваются различны типы правовой рефлексии в свете смены основных исследовательских парадигм. Для специалистов в области гуманитарного знания и читателей, интересующихся вопросами философии права и теоретического правоведения.